Stem cell therapy: New way to treat damaged lungs
Washington DC, March 25: Scientists have found that the modern stem cell therapy could cure damaged lungs. This, in turn, raises hopes of a cure for the crippling chronic obstructive pulmonary disease (COPD) and cystic fibrosis.
Though still at a pre-clinical stage, these findings have important potential implications for the growth of treatment methods.
Lung damage due to chronic inflammation in conditions such as COPD and cystic fibrosis leads to reduced lung function and ultimately to a respiratory failure. Mesenchymal stem cell (MSC) therapy is currently being investigated as a hopeful therapeutic program for a number of degenerative lung diseases which are considered as incurable. But still, only limited data is available on the short and long-term effects of applying stem cell therapy in chronic respiratory ailments.
The latest research examined the effectiveness of MSC therapy in a rat model of chronic inflammatory lung disease, which exhibits some of the necessary features of diseases such as COPD and cystic fibrosis.
Researchers delivered stem cells intravenously to ENaC overexpressing mice at 4 and 6 weeks of age, before collecting samples tissue and cells from the lungs at 8 weeks. They compared these findings to a control group that did not receive the MSC treatment.
The effects showed that inflammation was significantly reduced in the group receiving MSC therapy. Cells counts for both monocytic cells and neutrophils, both signs of inflammation, were significantly reduced after MSC therapy. Analysis of lung tissue revealed a reduction in the mean linear intercept and other measures of lung destruction in MSC treated mice. As well as reducing inflammation in the lung, MSC therapy also resulted in significant improvements in lung structure, suggesting that this form of treatment has the potential to repair the damaged lung.
Dr Declan Doherty, from Queens University Belfast, UK, commented: “These preliminary findings demonstrate the potential effectiveness of MSC treatment as a means of repairing the damage caused by chronic lung diseases such as COPD. The ability to counteract inflammation in the lungs by utilising the combined anti-inflammatory and reparative properties of MSCs could potentially reduce the inflammatory response in individuals with chronic lung disease whilst also
The ability to counteract inflammation in the lungs by utilising the combined anti-inflammatory and reparative properties of MSCs could potentially reduce the inflammatory response in individuals with chronic lung disease whilst also restoring lung function in these patients. Although further research is needed to improve our understanding of how MSCs repair this damage, these findings suggest a promising role for MSC therapy in treating patients with chronic lung disease.” The findings were presented in Estoril, Portugal at the European Respiratory Society’s Lung Science Conference. (ANI)